MGP Database

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MGP001557

UniProt Annotations

Entry Information
Gene Nameisopentenyl-diphosphate delta isomerase 1
Protein EntryIDI1_HUMAN
UniProt IDQ13907
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13907-1; Sequence=Displayed; Name=2; IsoId=Q13907-2; Sequence=VSP_037889; Note=Ref.8 (AAI07894) sequence is in conflict in position: 39:V->G. {ECO:0000305};
Catalytic ActivityIsopentenyl diphosphate = dimethylallyl diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:8806705}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000269|PubMed:8806705};
FunctionCatalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). {ECO:0000269|PubMed:8806705}.
PathwayIsoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.
Sequence CautionSequence=AAH57827.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK29357.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK49434.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK49435.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP35407.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA34890.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the IPP isomerase type 1 family. {ECO:0000305}.
SimilarityContains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule:PRU00794}.
Subcellular LocationPeroxisome.
SubunitMonomer. {ECO:0000269|PubMed:17250851}.
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