MGP Database

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MGP001585

Ontology/Pathway Information

Entrez Gene ID3479
Gene Nameinsulin-like growth factor 1 (somatomedin C)
Gene Symbol IGF1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 NAS:UniProtKBCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0016942 IC:BHF-UCLCinsulin-like growth factor binding protein complex
GO:0005886 TAS:ReactomeCplasma membrane
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0005179 IDA:BHF-UCLFhormone activity
GO:0005159 IPI:BHF-UCLFinsulin-like growth factor receptor binding
GO:0005158 IPI:BHF-UCLFinsulin receptor binding
GO:0005178 IDA:BHF-UCLFintegrin binding
GO:0007596 TAS:ReactomePblood coagulation
GO:0001974 IEA:EnsemblPblood vessel remodeling
GO:0035630 IDA:BHF-UCLPbone mineralization involved in bone maturation
GO:0048754 IEA:EnsemblPbranching morphogenesis of an epithelial tube
GO:0001775 IDA:MGIPcell activation
GO:0006928 TAS:ProtIncPcellular component movement
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0050650 IEA:EnsemblPchondroitin sulfate proteoglycan biosynthetic process
GO:0006260 TAS:ProtIncPDNA replication
GO:0031017 IEA:EnsemblPexocrine pancreas development
GO:0097192 IEA:EnsemblPextrinsic apoptotic signaling pathway in absence of ligand
GO:0010001 IEA:EnsemblPglial cell differentiation
GO:0009441 TAS:ProtIncPglycolate metabolic process
GO:0048839 IEA:EnsemblPinner ear development
GO:0048009 IEA:EnsemblPinsulin-like growth factor receptor signaling pathway
GO:0048286 IEA:EnsemblPlung alveolus development
GO:0060463 IEA:EnsemblPlung lobe morphogenesis
GO:0060426 IEA:EnsemblPlung vasculature development
GO:0030879 IEA:EnsemblPmammary gland development
GO:0035264 IEA:EnsemblPmulticellular organism growth
GO:0014896 IMP:BHF-UCLPmuscle hypertrophy
GO:0007517 TAS:ProtIncPmuscle organ development
GO:0045445 IDA:BHF-UCLPmyoblast differentiation
GO:0051450 IDA:BHF-UCLPmyoblast proliferation
GO:0014904 IDA:BHF-UCLPmyotube cell development
GO:0060766 IEA:EnsemblPnegative regulation of androgen receptor signaling pathway
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:0070373 IEA:EnsemblPnegative regulation of ERK1 and ERK2 cascade
GO:2001237 IDA:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway
GO:0060283 IMP:AgBasePnegative regulation of oocyte development
GO:0090201 ISS:UniProtKBPnegative regulation of release of cytochrome c from mitochondria
GO:0034392 IDA:BHF-UCLPnegative regulation of smooth muscle cell apoptotic process
GO:0048015 IDA:BHF-UCLPphosphatidylinositol-mediated signaling
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0042104 IDA:BHF-UCLPpositive regulation of activated T cell proliferation
GO:0070886 IDA:UniProtKBPpositive regulation of calcineurin-NFAT signaling cascade
GO:0010613 IDA:UniProtKBPpositive regulation of cardiac muscle hypertrophy
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0021940 IEA:EnsemblPpositive regulation of cerebellar granule cell precursor proliferation
GO:0043388 IDA:UniProtKBPpositive regulation of DNA binding
GO:0045740 IDA:BHF-UCLPpositive regulation of DNA replication
GO:0050679 IDA:BHF-UCLPpositive regulation of epithelial cell proliferation
GO:0048146 IDA:BHF-UCLPpositive regulation of fibroblast proliferation
GO:0046326 IDA:UniProtKBPpositive regulation of glucose import
GO:0045725 IDA:UniProtKBPpositive regulation of glycogen biosynthetic process
GO:0045821 IDA:BHF-UCLPpositive regulation of glycolytic process
GO:0043568 IDA:BHF-UCLPpositive regulation of insulin-like growth factor receptor signaling pathway
GO:0043410 IDA:UniProtKBPpositive regulation of MAPK cascade
GO:0045840 IDA:UniProtKBPpositive regulation of mitosis
GO:2000288 IEA:EnsemblPpositive regulation of myoblast proliferation
GO:0045669 IDA:BHF-UCLPpositive regulation of osteoblast differentiation
GO:0050731 IDA:BHF-UCLPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0014068 IDA:BHF-UCLPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0033160 IDA:UniProtKBPpositive regulation of protein import into nucleus, translocation
GO:0051897 IEA:EnsemblPpositive regulation of protein kinase B signaling
GO:0046579 IDA:BHF-UCLPpositive regulation of Ras protein signal transduction
GO:0014911 IDA:BHF-UCLPpositive regulation of smooth muscle cell migration
GO:0048661 IDA:BHF-UCLPpositive regulation of smooth muscle cell proliferation
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0042523 IDA:BHF-UCLPpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0060527 IEA:EnsemblPprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736 IEA:EnsemblPprostate gland growth
GO:0060741 IEA:EnsemblPprostate gland stromal morphogenesis
GO:0030166 IDA:BHF-UCLPproteoglycan biosynthetic process
GO:0007265 TAS:ProtIncPRas protein signal transduction
GO:0032878 IEA:EnsemblPregulation of establishment or maintenance of cell polarity
GO:0010468 IMP:AgBasePregulation of gene expression
GO:0040014 IEP:BHF-UCLPregulation of multicellular organism growth
GO:0007165 TAS:ProtIncPsignal transduction
GO:0014834 IDA:BHF-UCLPskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0001501 TAS:ProtIncPskeletal system development
GO:0060510 IEA:EnsemblPType II pneumocyte differentiation
GO:0060509 IEA:EnsemblPType I pneumocyte differentiation
GO:0030104 IEA:EnsemblPwater homeostasis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_150203IRS-related events triggered by IGF1R
REACT_17015Metabolism of proteins
REACT_160078Peptide hormone metabolism
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_15428Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_150139SHC-related events triggered by IGF1R
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_111102Signal Transduction
REACT_19189Synthesis, secretion, and deacylation of Ghrelin
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