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MGP001591

UniProt Annotations

Entry Information
Gene Nameinsulin-like growth factor binding protein 2, 36kDa
Protein EntryIBP2_HUMAN
UniProt IDP18065
SpeciesHuman
Comments
Comment typeDescription
DomainThe C-terminus is required for IGF-binding and growth inhibition. {ECO:0000269|PubMed:19081843}.
FunctionInhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. {ECO:0000269|PubMed:19081843}.
InteractionQ9C086:INO80B; NbExp=4; IntAct=EBI-2504392, EBI-715611;
PtmO-glycosylated. {ECO:0000269|PubMed:1726837}.
SimilarityContains 1 IGFBP N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00653}.
SimilarityContains 1 thyroglobulin type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00500}.
Subcellular LocationSecreted.
SubunitBinds IGF2 more than IGF1.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igfbp2/";
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