MGP Database

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MGP001592

Ontology/Pathway Information

Entrez Gene ID3486
Gene Nameinsulin-like growth factor binding protein 3
Gene Symbol IGFBP3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 NAS:UniProtKBCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016942 IC:BHF-UCLCinsulin-like growth factor binding protein complex
GO:0005634 IDA:MGICnucleus
GO:0001968 IBA:GO_CentralFfibronectin binding
GO:0005520 NAS:UniProtKBFinsulin-like growth factor binding
GO:0031994 IPI:BHF-UCLFinsulin-like growth factor I binding
GO:0031995 IBA:GO_CentralFinsulin-like growth factor II binding
GO:0046872 NAS:UniProtKBFmetal ion binding
GO:0008160 IDA:UniProtKBFprotein tyrosine phosphatase activator activity
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0008285 IGI:MGIPnegative regulation of cell proliferation
GO:0001933 IDA:MGIPnegative regulation of protein phosphorylation
GO:0009968 NAS:UniProtKBPnegative regulation of signal transduction
GO:0014912 IDA:BHF-UCLPnegative regulation of smooth muscle cell migration
GO:0048662 IDA:BHF-UCLPnegative regulation of smooth muscle cell proliferation
GO:0001649 IEA:EnsemblPosteoblast differentiation
GO:0043065 IMP:UniProtKBPpositive regulation of apoptotic process
GO:0043085 IDA:GOCPpositive regulation of catalytic activity
GO:0043568 IEA:EnsemblPpositive regulation of insulin-like growth factor receptor signaling pathway
GO:0043410 IEA:EnsemblPpositive regulation of MAPK cascade
GO:0045663 IDA:UniProtKBPpositive regulation of myoblast differentiation
GO:0006468 IDA:MGIPprotein phosphorylation
GO:0001558 IEA:EnsemblPregulation of cell growth
GO:0010906 IEA:EnsemblPregulation of glucose metabolic process
GO:0043567 IBA:GO_CentralPregulation of insulin-like growth factor receptor signaling pathway
GO:0044342 IEA:EnsemblPtype B pancreatic cell proliferation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_17015Metabolism of proteins
REACT_15428Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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