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MGP001592

UniProt Annotations

Entry Information
Gene Nameinsulin-like growth factor binding protein 3
Protein EntryIBP3_HUMAN
UniProt IDP17936
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P17936-1; Sequence=Displayed; Name=2; IsoId=P17936-2; Sequence=VSP_047293; Note=Gene prediction based on EST data.;
Developmental StageIGFBP3 levels are higher during extrauterine life and peak during puberty.
DomainThe thyroglobulin type-1 domain mediates interaction with HN.
FunctionIGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269|PubMed:20353938}.
InductionUp-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters.
InteractionP00533:EGFR; NbExp=3; IntAct=EBI-715709, EBI-297353; P78527:PRKDC; NbExp=2; IntAct=EBI-715709, EBI-352053;
PtmPhosphorylation sites are present in the extracellular medium.
SimilarityContains 1 IGFBP N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00653}.
SimilarityContains 1 thyroglobulin type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00500}.
Subcellular LocationSecreted {ECO:0000269|PubMed:20353938}.
SubunitInteracts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219. {ECO:0000250, ECO:0000269|PubMed:14561895, ECO:0000269|PubMed:1726837, ECO:0000269|PubMed:20353938}.
Tissue SpecificityExpressed by most tissues. Present in plasma.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igfbp3/";
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IGFBP3";
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