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MGP001593

Record overview

MGPD IDMGP001593
Gene ID3487
SpeciesHomo sapiens (Human)
Gene Nameinsulin-like growth factor binding protein 4
Gene Symbol IGFBP4
SynonymsBP-4; IBP4; IGFBP-4; HT29-IGFBP;
Alternate namesinsulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4;
Chromosome17
Map Location17q21.2
SummaryThis gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IGFBP4

Proteins

insulin-like growth factor-binding protein 4 precursor
Refseq ID:NP_001543
Protein GI:62243290
UniProt ID:P22692
mRNA ID:NM_001552
Length:258
RefSeq Status:
MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVC
MELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIP
IPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE
 
sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1978
peptide sequence: 
MLPLCLVAALLLAAGPGPSLG

mat_peptide: 22..258
product: insulin-like growth factor-binding protein 4
calculated_mol_wt: 25975
peptide sequence: 
DEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEG
DHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDG
QRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE
 
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