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MGP001593

UniProt Annotations

Entry Information
Gene Nameinsulin-like growth factor binding protein 4
Protein EntryIBP4_HUMAN
UniProt IDP22692
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22692-1; Sequence=Displayed; Name=2; IsoId=P22692-2; Sequence=VSP_057034; Note=No experimental confirmation available.;
FunctionIGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
InductionBy forskolin and N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate, but not by 1,9 dideoxyforskolin. {ECO:0000269|PubMed:1726835}.
SimilarityContains 1 IGFBP N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00653}.
SimilarityContains 1 thyroglobulin type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00500}.
Subcellular LocationSecreted.
SubunitBinds IGF2 more than IGF1. {ECO:0000269|PubMed:15642270, ECO:0000269|PubMed:16924115}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igfbp4/";
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