MGP Database

MGP001594

Ontology/Pathway Information

Entrez Gene ID	3488
Gene Name	insulin-like growth factor binding protein 5
Gene Symbol	IGFBP5
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005576	NAS:UniProtKB	C	extracellular region
GO:0005615	IBA:GO_Central	C	extracellular space
GO:0016942	IC:BHF-UCL	C	insulin-like growth factor binding protein complex
GO:0001968	IBA:GO_Central	F	fibronectin binding
GO:0031994	IPI:BHF-UCL	F	insulin-like growth factor I binding
GO:0031995	IBA:GO_Central	F	insulin-like growth factor II binding
GO:0044267	TAS:Reactome	P	cellular protein metabolic process
GO:0071320	IDA:UniProtKB	P	cellular response to cAMP
GO:0071407	IDA:UniProtKB	P	cellular response to organic cyclic compound
GO:0042593	IEA:Ensembl	P	glucose homeostasis
GO:0006006	IEA:Ensembl	P	glucose metabolic process
GO:0031069	IEA:Ensembl	P	hair follicle morphogenesis
GO:0035556	IEA:Ensembl	P	intracellular signal transduction
GO:0060056	IEA:Ensembl	P	mammary gland involution
GO:0030336	IDA:BHF-UCL	P	negative regulation of cell migration
GO:0043569	IDA:BHF-UCL	P	negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045668	IEA:Ensembl	P	negative regulation of osteoblast differentiation
GO:0014912	IDA:BHF-UCL	P	negative regulation of smooth muscle cell migration
GO:0048662	IDA:BHF-UCL	P	negative regulation of smooth muscle cell proliferation
GO:0017148	IDA:BHF-UCL	P	negative regulation of translation
GO:0001649	IEA:Ensembl	P	osteoblast differentiation
GO:0043568	IEA:Ensembl	P	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0051897	IEA:Ensembl	P	positive regulation of protein kinase B signaling
GO:0001558	IEA:Ensembl	P	regulation of cell growth
GO:0010906	IEA:Ensembl	P	regulation of glucose metabolic process
GO:0007165	NAS:ProtInc	P	signal transduction
GO:0048630	IEA:Ensembl	P	skeletal muscle tissue growth
GO:0051146	IEA:Ensembl	P	striated muscle cell differentiation
GO:0044342	IEA:Ensembl	P	type B pancreatic cell proliferation

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_17015	Metabolism of proteins
REACT_15428	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)