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MGP001594

UniProt Annotations

Entry Information
Gene Nameinsulin-like growth factor binding protein 5
Protein EntryIBP5_HUMAN
UniProt IDP24593
SpeciesHuman
Comments
Comment typeDescription
FunctionIGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
SimilarityContains 1 IGFBP N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00653}.
SimilarityContains 1 thyroglobulin type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00500}.
Subcellular LocationSecreted.
Tissue SpecificityOsteosarcoma, and at lower levels in liver, kidney and brain.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igfbp5/";
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