MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001601

Ontology/Pathway Information

Entrez Gene ID3553
Gene Nameinterleukin 1, beta
Gene Symbol IL1B
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005576 NAS:UniProtKBCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0030141 IEA:EnsemblCsecretory granule
GO:0005125 IDA:BHF-UCLFcytokine activity
GO:0005149 NAS:UniProtKBFinterleukin-1 receptor binding
GO:0019904 IPI:UniProtKBFprotein domain specific binding
GO:0000187 IDA:BHF-UCLPactivation of MAPK activity
GO:0006915 TAS:ProtIncPapoptotic process
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0035690 IDA:MGIPcellular response to drug
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0071407 IDA:UniProtKBPcellular response to organic cyclic compound
GO:0071310 IDA:MGIPcellular response to organic substance
GO:0019221 IDA:BHF-UCLPcytokine-mediated signaling pathway
GO:0035234 IEA:EnsemblPectopic germ cell programmed cell death
GO:0007566 TAS:BHF-UCLPembryo implantation
GO:0097192 IEA:EnsemblPextrinsic apoptotic signaling pathway in absence of ligand
GO:0001660 IEA:UniProtKB-KWPfever generation
GO:0030213 IDA:UniProtKBPhyaluronan biosynthetic process
GO:0006955 IEA:InterProPimmune response
GO:0006954 IDA:UniProtKBPinflammatory response
GO:0032611 IEA:EnsemblPinterleukin-1 beta production
GO:0031663 IDA:UniProtKBPlipopolysaccharide-mediated signaling pathway
GO:0000165 IMP:UniProtKBPMAPK cascade
GO:0070487 IDA:UniProtKBPmonocyte aggregation
GO:0070164 ISS:BHF-UCLPnegative regulation of adiponectin secretion
GO:0008285 IDA:BHF-UCLPnegative regulation of cell proliferation
GO:2001240 IDA:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0010829 ISS:BHF-UCLPnegative regulation of glucose transport
GO:0046627 ISS:BHF-UCLPnegative regulation of insulin receptor signaling pathway
GO:0050995 IDA:BHF-UCLPnegative regulation of lipid catabolic process
GO:0045833 ISS:BHF-UCLPnegative regulation of lipid metabolic process
GO:0043407 ISS:BHF-UCLPnegative regulation of MAP kinase activity
GO:0030593 IEA:EnsemblPneutrophil chemotaxis
GO:0045766 ISS:BHF-UCLPpositive regulation of angiogenesis
GO:0060559 IDA:BHF-UCLPpositive regulation of calcidiol 1-monooxygenase activity
GO:0060355 NAS:BHF-UCLPpositive regulation of cell adhesion molecule production
GO:0045080 IEA:EnsemblPpositive regulation of chemokine biosynthetic process
GO:0031622 ISS:BHF-UCLPpositive regulation of fever generation
GO:0010628 IDA:AgBasePpositive regulation of gene expression
GO:0032725 IDA:BHF-UCLPpositive regulation of granulocyte macrophage colony-stimulating factor production
GO:0034116 IDA:UniProtKBPpositive regulation of heterotypic cell-cell adhesion
GO:0035066 NAS:BHF-UCLPpositive regulation of histone acetylation
GO:0033129 NAS:BHF-UCLPpositive regulation of histone phosphorylation
GO:0043123 IBA:GO_CentralPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032729 IDA:BHF-UCLPpositive regulation of interferon-gamma production
GO:0045086 IMP:BHF-UCLPpositive regulation of interleukin-2 biosynthetic process
GO:0045410 IEA:EnsemblPpositive regulation of interleukin-6 biosynthetic process
GO:0032755 TAS:BHF-UCLPpositive regulation of interleukin-6 production
GO:0032757 IDA:UniProtKBPpositive regulation of interleukin-8 production
GO:0046330 IBA:GO_CentralPpositive regulation of JNK cascade
GO:0050996 ISS:BHF-UCLPpositive regulation of lipid catabolic process
GO:0051044 IDA:BHF-UCLPpositive regulation of membrane protein ectodomain proteolysis
GO:0045840 IMP:BHF-UCLPpositive regulation of mitosis
GO:0071639 IDA:UniProtKBPpositive regulation of monocyte chemotactic protein-1 production
GO:0035505 IDA:BHF-UCLPpositive regulation of myosin light chain kinase activity
GO:0042346 IDA:BHF-UCLPpositive regulation of NF-kappaB import into nucleus
GO:0051092 IDA:BHF-UCLPpositive regulation of NF-kappaB transcription factor activity
GO:0045429 IDA:BHF-UCLPpositive regulation of nitric oxide biosynthetic process
GO:0032308 ISS:BHF-UCLPpositive regulation of prostaglandin secretion
GO:0046827 NAS:BHF-UCLPpositive regulation of protein export from nucleus
GO:0001934 IDA:BHF-UCLPpositive regulation of protein phosphorylation
GO:0051091 IDA:BHF-UCLPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0002711 IC:BHF-UCLPpositive regulation of T cell mediated immunity
GO:0042102 IDA:BHF-UCLPpositive regulation of T cell proliferation
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IEA:EnsemblPpositive regulation of transcription from RNA polymerase II promoter
GO:0030949 IC:BHF-UCLPpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0010575 IDA:BHF-UCLPpositive regulation vascular endothelial growth factor production
GO:0043491 IMP:UniProtKBPprotein kinase B signaling
GO:0043122 IDA:BHF-UCLPregulation of I-kappaB kinase/NF-kappaB signaling
GO:0050796 IDA:BHF-UCLPregulation of insulin secretion
GO:0033198 IEA:EnsemblPresponse to ATP
GO:0009743 IEA:EnsemblPresponse to carbohydrate
GO:0030730 IDA:BHF-UCLPsequestering of triglyceride
GO:0007165 TAS:ProtIncPsignal transduction
GO:0014805 NAS:BHF-UCLPsmooth muscle adaptation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_23950Interleukin-1 processing
REACT_22442Interleukin-1 signaling
REACT_22232Signaling by Interleukins
  logo