MGP Database

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MGP001601

UniProt Annotations

Entry Information
Gene Nameinterleukin 1, beta
Protein EntryIL1B_HUMAN
UniProt IDP01584
SpeciesHuman
Comments
Comment typeDescription
DomainThe similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
FunctionProduced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. {ECO:0000269|PubMed:3920526}.
SimilarityBelongs to the IL-1 family. {ECO:0000305}.
Subcellular LocationSecreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
SubunitMonomer. Interacts with MEFV. {ECO:0000269|PubMed:17431422, ECO:0000269|PubMed:20802483}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/IL1BID40950ch2q13.html";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1b/";
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1B";
Web ResourceName=Wikipedia; Note=Interleukin-1 entry; URL="http://en.wikipedia.org/wiki/Interleukin_1";
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