MGP Database

MGP001603

Record overview

MGPD ID	MGP001603
Gene ID	3557
Species	Homo sapiens (Human)
Gene Name	interleukin 1 receptor antagonist
Gene Symbol	IL1RN
Synonyms	DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA;
Alternate names	interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); type II interleukin-1 receptor antagonist;
Chromosome	2
Map Location	2q14.2
Summary	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for IL1RN

Proteins

interleukin-1 receptor antagonist protein isoform 1 precursor

Refseq ID:	NP_776214
Protein GI:	27894319
UniProt ID:	P18510
mRNA ID:	NM_173842
Length:	177
RefSeq Status:

`MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDE TRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2947
peptide sequence: 
MEICRGLRSHLITLLLFLFHSETIC

mat_peptide: 26..177
product: interleukin-1 receptor antagonist protein isoform 1
calculated_mol_wt: 17127
peptide sequence: 
RPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAF
IRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE

interleukin-1 receptor antagonist protein isoform 2

Refseq ID:	NP_776213
Protein GI:	27894319
UniProt ID:	P18510
mRNA ID:	NM_173841
Length:	177
RefSeq Status:

`MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDE TRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2947
peptide sequence: 
MEICRGLRSHLITLLLFLFHSETIC

mat_peptide: 26..177
product: interleukin-1 receptor antagonist protein isoform 1
calculated_mol_wt: 17127
peptide sequence: 
RPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAF
IRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE

interleukin-1 receptor antagonist protein isoform 3

Refseq ID:	NP_000568
Protein GI:	10835147
UniProt ID:	P18510
mRNA ID:	NM_000577
Length:	159
RefSeq Status:

`MALETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRK QDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2947
peptide sequence: 
MEICRGLRSHLITLLLFLFHSETIC

mat_peptide: 26..177
product: interleukin-1 receptor antagonist protein isoform 1
calculated_mol_wt: 17127
peptide sequence: 
RPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAF
IRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE

interleukin-1 receptor antagonist protein isoform 4

Refseq ID:	NP_776215
Protein GI:	27894321
UniProt ID:	P18510
mRNA ID:	NM_173843
Length:	143
RefSeq Status:

`MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTT SFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE`