MGP Database

MGP001603

Ontology/Pathway Information

Entrez Gene ID	3557
Gene Name	interleukin 1 receptor antagonist
Gene Symbol	IL1RN
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IEA:UniProtKB-SubCell	C	cytoplasm
GO:0005615	IDA:BHF-UCL	C	extracellular space
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005622	NAS:UniProtKB	C	intracellular
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0005125	IBA:GO_Central	F	cytokine activity
GO:0005152	IDA:BHF-UCL	F	interleukin-1 receptor antagonist activity
GO:0005149	IDA:BHF-UCL	F	interleukin-1 receptor binding
GO:0045353	IDA:BHF-UCL	F	interleukin-1 Type II receptor antagonist activity
GO:0005151	IPI:BHF-UCL	F	interleukin-1, Type II receptor binding
GO:0045352	IDA:BHF-UCL	F	interleukin-1 Type I receptor antagonist activity
GO:0005150	IPI:BHF-UCL	F	interleukin-1, Type I receptor binding
GO:0006953	IDA:BHF-UCL	P	acute-phase response
GO:0019752	IEA:Ensembl	P	carboxylic acid metabolic process
GO:0071874	IEA:Ensembl	P	cellular response to norepinephrine stimulus
GO:0002439	IEA:Ensembl	P	chronic inflammatory response to antigenic stimulus
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0001660	IEA:Ensembl	P	fever generation
GO:0006955	NAS:UniProtKB	P	immune response
GO:0030073	IEA:Ensembl	P	insulin secretion
GO:0006629	IEA:Ensembl	P	lipid metabolic process
GO:0007613	IEA:Ensembl	P	memory
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0030336	IEA:Ensembl	P	negative regulation of cell migration
GO:0001960	IDA:GOC	P	negative regulation of cytokine-mediated signaling pathway
GO:0014050	IEA:Ensembl	P	negative regulation of glutamate secretion
GO:0034115	IDA:BHF-UCL	P	negative regulation of heterotypic cell-cell adhesion
GO:2000660	IDA:BHF-UCL	P	negative regulation of interleukin-1-mediated signaling pathway
GO:0045837	IEA:Ensembl	P	negative regulation of membrane potential
GO:0043507	IEA:Ensembl	P	positive regulation of JUN kinase activity
GO:0014823	IEA:Ensembl	P	response to activity
GO:0042493	IEA:Ensembl	P	response to drug
GO:0051384	IDA:BHF-UCL	P	response to glucocorticoid
GO:0070555	IEA:Ensembl	P	response to interleukin-1
GO:0070670	IEA:Ensembl	P	response to interleukin-4
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0042594	IEA:Ensembl	P	response to starvation
GO:0019233	IEA:Ensembl	P	sensory perception of pain

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_75790	Cytokine Signaling in Immune system
REACT_6900	Immune System
REACT_22442	Interleukin-1 signaling
REACT_22232	Signaling by Interleukins