MGP Database

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MGP001614

Ontology/Pathway Information

Entrez Gene ID3570
Gene Nameinterleukin 6 receptor
Gene Symbol IL6R
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016324 IDA:BHF-UCLCapical plasma membrane
GO:0016323 IEA:UniProtKB-SubCellCbasolateral plasma membrane
GO:0009986 IEA:EnsemblCcell surface
GO:0070110 IDA:BHF-UCLCciliary neurotrophic factor receptor complex
GO:0005576 IDA:UniProtKBCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0005896 IDA:BHF-UCLCinterleukin-6 receptor complex
GO:0005886 TAS:ReactomeCplasma membrane
GO:0070119 IPI:BHF-UCLFciliary neurotrophic factor binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0019981 IPI:BHF-UCLFinterleukin-6 binding
GO:0004915 IEA:EnsemblFinterleukin-6 receptor activity
GO:0042803 IPI:BHF-UCLFprotein homodimerization activity
GO:0006953 TAS:BHF-UCLPacute-phase response
GO:0070120 IMP:BHF-UCLPciliary neurotrophic factor-mediated signaling pathway
GO:0019221 IDA:BHF-UCLPcytokine-mediated signaling pathway
GO:0050829 IEP:BHF-UCLPdefense response to Gram-negative bacterium
GO:0050830 IEP:BHF-UCLPdefense response to Gram-positive bacterium
GO:0031018 IMP:BHF-UCLPendocrine pancreas development
GO:0097191 TAS:BHF-UCLPextrinsic apoptotic signaling pathway
GO:0002384 TAS:BHF-UCLPhepatic immune response
GO:0070102 IMP:BHF-UCLPinterleukin-6-mediated signaling pathway
GO:0002548 IC:BHF-UCLPmonocyte chemotaxis
GO:0032966 IDA:BHF-UCLPnegative regulation of collagen biosynthetic process
GO:0032717 IEP:BHF-UCLPnegative regulation of interleukin-8 production
GO:0002446 IC:BHF-UCLPneutrophil mediated immunity
GO:0010536 IDA:BHF-UCLPpositive regulation of activation of Janus kinase activity
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0032722 IDA:BHF-UCLPpositive regulation of chemokine production
GO:0032755 IDA:BHF-UCLPpositive regulation of interleukin-6 production
GO:0002690 TAS:BHF-UCLPpositive regulation of leukocyte chemotaxis
GO:0043410 IDA:BHF-UCLPpositive regulation of MAPK cascade
GO:0045669 TAS:BHF-UCLPpositive regulation of osteoblast differentiation
GO:0050731 IDA:BHF-UCLPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0048661 IDA:BHF-UCLPpositive regulation of smooth muscle cell proliferation
GO:0042517 IMP:BHF-UCLPpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0034097 IDA:BHF-UCLPresponse to cytokine
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_12002ARMS-mediated activation
REACT_18266Axon guidance
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_1391ERK1 activation
REACT_1183ERK2 activation
REACT_1482ERK activation
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_12076Frs2-mediated activation
REACT_21247FRS2-mediated cascade
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_27283Interleukin-2 signaling
REACT_27307Interleukin-6 signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_21308MAP kinase activation in TLR cascade
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_18334NCAM signaling for neurite out-growth
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12005Prolonged ERK activation events
REACT_634RAF/MAP kinase cascade
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_524SOS-mediated signalling
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
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