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MGP001614

UniProt Annotations

Entry Information
Gene Nameinterleukin 6 receptor
Protein EntryIL6RA_HUMAN
UniProt IDP08887
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P08887-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P08887-2; Sequence=VSP_001682, VSP_001683;
DomainThe two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.
FunctionLow concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
FunctionPart of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
InteractionP05231:IL6; NbExp=5; IntAct=EBI-299383, EBI-720533; Q2HRC7:K2 (xeno); NbExp=3; IntAct=EBI-299383, EBI-9007403;
PolymorphismGenetic variations in IL6R define the IL6 serum level quantitative trait locus [MIM:614752].
PolymorphismGenetic variations in IL6R determine soluble IL6R serum levels [MIM:614689].
PtmA short soluble form may also be released from the membrane by proteolysis.
SimilarityBelongs to the type I cytokine receptor family. Type 3 subfamily. {ECO:0000305}.
SimilarityContains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
SimilarityContains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
Subcellular LocationIsoform 1: Basolateral cell membrane; Single-pass type I membrane protein.
Subcellular LocationIsoform 2: Secreted.
SubunitHexamer of two molecules each of IL6, IL6R and IL6ST.
Tissue SpecificityIsoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
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