MGP Database

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MGP001615

Ontology/Pathway Information

Entrez Gene ID3572
Gene Nameinterleukin 6 signal transducer
Gene Symbol IL6ST
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0070110 IDA:BHF-UCLCciliary neurotrophic factor receptor complex
GO:0030425 IEA:EnsemblCdendrite
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005896 IDA:BHF-UCLCinterleukin-6 receptor complex
GO:0016020 IDA:UniProtKBCmembrane
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005900 IDA:BHF-UCLConcostatin-M receptor complex
GO:0005886 TAS:ReactomeCplasma membrane
GO:0004897 IDA:BHF-UCLFciliary neurotrophic factor receptor activity
GO:0005127 IPI:BHF-UCLFciliary neurotrophic factor receptor binding
GO:0019838 IPI:BHF-UCLFgrowth factor binding
GO:0004921 IEA:EnsemblFinterleukin-11 receptor activity
GO:0045509 IC:BHF-UCLFinterleukin-27 receptor activity
GO:0042803 TAS:BHF-UCLFprotein homodimerization activity
GO:0070120 IDA:BHF-UCLPciliary neurotrophic factor-mediated signaling pathway
GO:0019221 IDA:BHF-UCLPcytokine-mediated signaling pathway
GO:0005977 IEA:EnsemblPglycogen metabolic process
GO:0070106 IMP:BHF-UCLPinterleukin-27-mediated signaling pathway
GO:0070102 IMP:BHF-UCLPinterleukin-6-mediated signaling pathway
GO:0048861 IDA:BHF-UCLPleukemia inhibitory factor signaling pathway
GO:0043066 TAS:BHF-UCLPnegative regulation of apoptotic process
GO:0070104 IDA:BHF-UCLPnegative regulation of interleukin-6-mediated signaling pathway
GO:0038165 IMP:BHF-UCLPoncostatin-M-mediated signaling pathway
GO:0002675 IC:BHF-UCLPpositive regulation of acute inflammatory response
GO:0002821 IC:BHF-UCLPpositive regulation of adaptive immune response
GO:0048711 IEA:EnsemblPpositive regulation of astrocyte differentiation
GO:0010613 TAS:BHF-UCLPpositive regulation of cardiac muscle hypertrophy
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0045669 IMP:BHF-UCLPpositive regulation of osteoblast differentiation
GO:0042102 IMP:BHF-UCLPpositive regulation of T cell proliferation
GO:0042511 IMP:BHF-UCLPpositive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 IMP:BHF-UCLPpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0010575 TAS:BHF-UCLPpositive regulation vascular endothelial growth factor production
GO:0008593 IEA:EnsemblPregulation of Notch signaling pathway
GO:0034097 IDA:BHF-UCLPresponse to cytokine
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_27307Interleukin-6 signaling
REACT_22232Signaling by Interleukins
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