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MGP001615

UniProt Annotations

Entry Information
Gene Nameinterleukin 6 signal transducer
Protein EntryIL6RB_HUMAN
UniProt IDP40189
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P40189-1; Sequence=Displayed; Name=2; Synonyms=GP130-RAPS; IsoId=P40189-2; Sequence=VSP_001684, VSP_001685; Name=3; IsoId=P40189-3; Sequence=VSP_043716;
DomainThe box 1 motif is required for JAK interaction and/or activation.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.
FunctionSignal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. {ECO:0000250}.
InductionLIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor. {ECO:0000269|PubMed:8999038}.
InteractionQ2HRC7:K2 (xeno); NbExp=2; IntAct=EBI-1030834, EBI-9007403; P42227:Stat3 (xeno); NbExp=4; IntAct=EBI-1030834, EBI-602878;
PtmHeavily N-glycosylated. {ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:11251120, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218}.
PtmPhosphorylation of Ser-782 down-regulates cell surface expression. {ECO:0000269|PubMed:10811661, ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:18088087, ECO:0000269|PubMed:20068231}.
SimilarityBelongs to the type I cytokine receptor family. Type 2 subfamily. {ECO:0000305}.
SimilarityContains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
SimilarityContains 5 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
Subcellular LocationIsoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular LocationIsoform 2: Secreted.
SubunitInteracts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK. {ECO:0000250, ECO:0000269|PubMed:11238858, ECO:0000269|PubMed:11251120, ECO:0000269|PubMed:12829785, ECO:0000269|PubMed:14527405, ECO:0000269|PubMed:8999038, ECO:0000269|PubMed:9406996}.
Tissue SpecificityFound in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
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