MGP Database

MGP001627

Ontology/Pathway Information

Entrez Gene ID	3620
Gene Name	indoleamine 2,3-dioxygenase 1
Gene Symbol	IDO1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0030485	IEA:Ensembl	C	smooth muscle contractile fiber
GO:0032421	IEA:Ensembl	C	stereocilium bundle
GO:0009055	TAS:UniProtKB	F	electron carrier activity
GO:0020037	IEA:InterPro	F	heme binding
GO:0033754	IMP:UniProtKB	F	indoleamine 2,3-dioxygenase activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0004833	EXP:Reactome	F	tryptophan 2,3-dioxygenase activity
GO:0034641	TAS:Reactome	P	cellular nitrogen compound metabolic process
GO:0002534	IEA:Ensembl	P	cytokine production involved in inflammatory response
GO:0007565	TAS:ProtInc	P	female pregnancy
GO:0034276	IEA:Ensembl	P	kynurenic acid biosynthetic process
GO:0033555	IEA:Ensembl	P	multicellular organismal response to stress
GO:0032693	IEA:Ensembl	P	negative regulation of interleukin-10 production
GO:0070233	IEA:Ensembl	P	negative regulation of T cell apoptotic process
GO:0042130	IEA:Ensembl	P	negative regulation of T cell proliferation
GO:0002678	IEA:Ensembl	P	positive regulation of chronic inflammatory response
GO:0032735	IEA:Ensembl	P	positive regulation of interleukin-12 production
GO:0070234	IMP:UniProtKB	P	positive regulation of T cell apoptotic process
GO:0002666	IEA:Ensembl	P	positive regulation of T cell tolerance induction
GO:0002830	IEA:Ensembl	P	positive regulation of type 2 immune response
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0036269	IEA:Ensembl	P	swimming behavior
GO:0006569	TAS:Reactome	P	tryptophan catabolic process
GO:0019441	IEA:UniProtKB-UniPathway	P	tryptophan catabolic process to kynurenine

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_13	Metabolism of amino acids and derivatives
REACT_916	Tryptophan catabolism

SMP Pathway Links

SMP ID	Description
SMP00063	Tryptophan Metabolism