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MGP001627

UniProt Annotations

Entry Information

Gene Name	indoleamine 2,3-dioxygenase 1
Protein Entry	I23O1_HUMAN
UniProt ID	P14902
Species	Human

Comments

Comment type	Description
Biophysicochemical Properties	Kinetic parameters: KM=21.23 uM for L-tryptophan {ECO:0000269\|PubMed:18026683}; KM=4.6 mM for D-tryptophan {ECO:0000269\|PubMed:18026683}; Note=Catalytic efficiency for L-tryptophan is 150 times higher than for D-tryptophan.;
Catalytic Activity	D-tryptophan + O(2) = N-formyl-D-kynurenine. {ECO:0000269\|PubMed:17671174}.
Catalytic Activity	L-tryptophan + O(2) = N-formyl-L-kynurenine. {ECO:0000269\|PubMed:17671174}.
Cofactor	Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 1 heme group per subunit.;
Enzyme Regulation	Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan). {ECO:0000269\|PubMed:17671174}.
Function	Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. {ECO:0000269\|PubMed:17671174}.
Induction	By IFNG/IFN-gamma. {ECO:0000269\|PubMed:2109605}.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Similarity	Belongs to the indoleamine 2,3-dioxygenase family. {ECO:0000305}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/IDO1ID40973ch8p11.html";