MGP Database

MGP001634

Record overview

MGPD IDMGP001634
Gene ID3630
SpeciesHomo sapiens (Human)
Gene Nameinsulin
Gene Symbol INS
SynonymsIDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10;
Alternate namesinsulin; preproinsulin; proinsulin;
Chromosome11
Map Location11p15.5
SummaryAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
OrthologsView orthologs and multiple alignments for INS

Proteins

insulin preproprotein
Refseq ID:NP_001172026
Protein GI:297374821
UniProt ID:P01308
mRNA ID:NM_001185097
Length:110
RefSeq Status:
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSIC
SLYQLENYCN
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2604
peptide sequence: 
MALWMRLLPLLALLALWGPDPAAA

mat_peptide: 25..54
product: insulin B chain
calculated_mol_wt: 3430
peptide sequence: 
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

mat_peptide: 57..87
product: C-peptide
calculated_mol_wt: 3020
peptide sequence: 
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ

mat_peptide: 90..110
product: insulin A chain
calculated_mol_wt: 2384
peptide sequence: 
GIVEQCCTSICSLYQLENYCN
 
insulin preproprotein
Refseq ID:NP_001278826
Protein GI:631226408
UniProt ID:P01308
mRNA ID:NM_001291897
Length:110
RefSeq Status:
Protein sequence is identical to GI:297374821 (mRNA isoform)
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2604
peptide sequence: 
MALWMRLLPLLALLALWGPDPAAA

mat_peptide: 25..54
product: insulin B chain
calculated_mol_wt: 3430
peptide sequence: 
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

mat_peptide: 57..87
product: C-peptide
calculated_mol_wt: 3020
peptide sequence: 
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ

mat_peptide: 90..110
product: insulin A chain
calculated_mol_wt: 2384
peptide sequence: 
GIVEQCCTSICSLYQLENYCN

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2604
peptide sequence: 
MALWMRLLPLLALLALWGPDPAAA

mat_peptide: 25..54
product: insulin B chain
calculated_mol_wt: 3430
peptide sequence: 
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

mat_peptide: 57..87
product: C-peptide
calculated_mol_wt: 3020
peptide sequence: 
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ

mat_peptide: 90..110
product: insulin A chain
calculated_mol_wt: 2384
peptide sequence: 
GIVEQCCTSICSLYQLENYCN

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2604
peptide sequence: 
MALWMRLLPLLALLALWGPDPAAA

mat_peptide: 25..54
product: insulin B chain
calculated_mol_wt: 3430
peptide sequence: 
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

mat_peptide: 57..87
product: C-peptide
calculated_mol_wt: 3020
peptide sequence: 
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ

mat_peptide: 90..110
product: insulin A chain
calculated_mol_wt: 2384
peptide sequence: 
GIVEQCCTSICSLYQLENYCN

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2604
peptide sequence: 
MALWMRLLPLLALLALWGPDPAAA

mat_peptide: 25..54
product: insulin B chain
calculated_mol_wt: 3430
peptide sequence: 
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

mat_peptide: 57..87
product: C-peptide
calculated_mol_wt: 3020
peptide sequence: 
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ

mat_peptide: 90..110
product: insulin A chain
calculated_mol_wt: 2384
peptide sequence: 
GIVEQCCTSICSLYQLENYCN
 
insulin preproprotein
Refseq ID:NP_001172027
Protein GI:297374823
UniProt ID:P01308
mRNA ID:NM_001185098
Length:110
RefSeq Status:
Protein sequence is identical to GI:297374821 (mRNA isoform)
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2604
peptide sequence: 
MALWMRLLPLLALLALWGPDPAAA

mat_peptide: 25..54
product: insulin B chain
calculated_mol_wt: 3430
peptide sequence: 
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

mat_peptide: 57..87
product: C-peptide
calculated_mol_wt: 3020
peptide sequence: 
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ

mat_peptide: 90..110
product: insulin A chain
calculated_mol_wt: 2384
peptide sequence: 
GIVEQCCTSICSLYQLENYCN

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2604
peptide sequence: 
MALWMRLLPLLALLALWGPDPAAA

mat_peptide: 25..54
product: insulin B chain
calculated_mol_wt: 3430
peptide sequence: 
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

mat_peptide: 57..87
product: C-peptide
calculated_mol_wt: 3020
peptide sequence: 
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ

mat_peptide: 90..110
product: insulin A chain
calculated_mol_wt: 2384
peptide sequence: 
GIVEQCCTSICSLYQLENYCN
 
insulin preproprotein
Refseq ID:NP_000198
Protein GI:4557671
UniProt ID:P01308
mRNA ID:NM_000207
Length:110
RefSeq Status:
Protein sequence is identical to GI:297374821 (mRNA isoform)
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2604
peptide sequence: 
MALWMRLLPLLALLALWGPDPAAA

mat_peptide: 25..54
product: insulin B chain
calculated_mol_wt: 3430
peptide sequence: 
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

mat_peptide: 57..87
product: C-peptide
calculated_mol_wt: 3020
peptide sequence: 
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ

mat_peptide: 90..110
product: insulin A chain
calculated_mol_wt: 2384
peptide sequence: 
GIVEQCCTSICSLYQLENYCN

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2604
peptide sequence: 
MALWMRLLPLLALLALWGPDPAAA

mat_peptide: 25..54
product: insulin B chain
calculated_mol_wt: 3430
peptide sequence: 
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

mat_peptide: 57..87
product: C-peptide
calculated_mol_wt: 3020
peptide sequence: 
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ

mat_peptide: 90..110
product: insulin A chain
calculated_mol_wt: 2384
peptide sequence: 
GIVEQCCTSICSLYQLENYCN

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2604
peptide sequence: 
MALWMRLLPLLALLALWGPDPAAA

mat_peptide: 25..54
product: insulin B chain
calculated_mol_wt: 3430
peptide sequence: 
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

mat_peptide: 57..87
product: C-peptide
calculated_mol_wt: 3020
peptide sequence: 
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ

mat_peptide: 90..110
product: insulin A chain
calculated_mol_wt: 2384
peptide sequence: 
GIVEQCCTSICSLYQLENYCN
 
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