MGP Database

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MGP001634

Ontology/Pathway Information

Entrez Gene ID3630
Gene Nameinsulin
Gene Symbol INS
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005788 TAS:ReactomeCendoplasmic reticulum lumen
GO:0031904 TAS:ReactomeCendosome lumen
GO:0005576 IC:UniProtKBCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0005796 TAS:ReactomeCGolgi lumen
GO:0034774 TAS:ReactomeCsecretory granule lumen
GO:0005179 NAS:UniProtKBFhormone activity
GO:0042802 IPI:IntActFidentical protein binding
GO:0005159 IPI:BHF-UCLFinsulin-like growth factor receptor binding
GO:0005158 IDA:UniProtKBFinsulin receptor binding
GO:0002020 IPI:UniProtKBFprotease binding
GO:0032148 IDA:BHF-UCLPactivation of protein kinase B activity
GO:0006953 IDA:BHF-UCLPacute-phase response
GO:0046631 IDA:UniProtKBPalpha-beta T cell activation
GO:0007267 IC:UniProtKBPcell-cell signaling
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0031018 TAS:ReactomePendocrine pancreas development
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0055089 IMP:BHF-UCLPfatty acid homeostasis
GO:0042593 IMP:BHF-UCLPglucose homeostasis
GO:0006006 IEA:UniProtKB-KWPglucose metabolic process
GO:0015758 IDA:UniProtKBPglucose transport
GO:0007186 IDA:BHF-UCLPG-protein coupled receptor signaling pathway
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0000165 IDA:BHF-UCLPMAPK cascade
GO:0002674 IDA:BHF-UCLPnegative regulation of acute inflammatory response
GO:0045922 IMP:BHF-UCLPnegative regulation of fatty acid metabolic process
GO:2000252 IDA:DFLATPnegative regulation of feeding behavior
GO:0045721 NAS:BHF-UCLPnegative regulation of gluconeogenesis
GO:0045818 IMP:BHF-UCLPnegative regulation of glycogen catabolic process
GO:0050995 IMP:AgBasePnegative regulation of lipid catabolic process
GO:0033861 IDA:BHF-UCLPnegative regulation of NAD(P)H oxidase activity
GO:1902176 NAS:BHF-UCLPnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0042177 IDA:UniProtKBPnegative regulation of protein catabolic process
GO:0032460 IDA:UniProtKBPnegative regulation of protein oligomerization
GO:0050709 IDA:BHF-UCLPnegative regulation of protein secretion
GO:0045861 IMP:BHF-UCLPnegative regulation of proteolysis
GO:0060266 IDA:BHF-UCLPnegative regulation of respiratory burst involved in inflammatory response
GO:0045908 NAS:UniProtKBPnegative regulation of vasodilation
GO:0090336 TAS:BHF-UCLPpositive regulation of brown fat cell differentiation
GO:0045597 NAS:BHF-UCLPpositive regulation of cell differentiation
GO:0030307 NAS:BHF-UCLPpositive regulation of cell growth
GO:0030335 ISS:BHF-UCLPpositive regulation of cell migration
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0032270 IMP:BHF-UCLPpositive regulation of cellular protein metabolic process
GO:0050715 IDA:UniProtKBPpositive regulation of cytokine secretion
GO:0045740 IDA:BHF-UCLPpositive regulation of DNA replication
GO:0046326 IDA:BHF-UCLPpositive regulation of glucose import
GO:0045725 IDA:BHF-UCLPpositive regulation of glycogen biosynthetic process
GO:0045821 IDA:BHF-UCLPpositive regulation of glycolytic process
GO:0046628 IDA:BHF-UCLPpositive regulation of insulin receptor signaling pathway
GO:0046889 NAS:BHF-UCLPpositive regulation of lipid biosynthetic process
GO:0043410 IDA:BHF-UCLPpositive regulation of MAPK cascade
GO:0045840 IDA:UniProtKBPpositive regulation of mitosis
GO:0051092 IDA:BHF-UCLPpositive regulation of NF-kappaB transcription factor activity
GO:0045429 NAS:UniProtKBPpositive regulation of nitric oxide biosynthetic process
GO:0051000 NAS:UniProtKBPpositive regulation of nitric-oxide synthase activity
GO:0090277 TAS:BHF-UCLPpositive regulation of peptide hormone secretion
GO:0050731 IDA:BHF-UCLPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0014068 IDA:BHF-UCLPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0031954 ISS:BHF-UCLPpositive regulation of protein autophosphorylation
GO:0051897 IDA:BHF-UCLPpositive regulation of protein kinase B signaling
GO:0060267 IDA:BHF-UCLPpositive regulation of respiratory burst
GO:0045909 NAS:UniProtKBPpositive regulation of vasodilation
GO:0006521 IMP:BHF-UCLPregulation of cellular amino acid metabolic process
GO:0050796 TAS:ReactomePregulation of insulin secretion
GO:0032880 IDA:BHF-UCLPregulation of protein localization
GO:0050708 IDA:UniProtKBPregulation of protein secretion
GO:0006355 NAS:BHF-UCLPregulation of transcription, DNA-templated
GO:0022898 IDA:BHF-UCLPregulation of transmembrane transporter activity
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0042060 IDA:BHF-UCLPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111045Developmental Biology
REACT_15550Insulin processing
REACT_1109Insulin receptor recycling
REACT_1195Insulin receptor signalling cascade
REACT_1505Integration of energy metabolism
REACT_570IRS activation
REACT_762IRS-related events
REACT_111217Metabolism
REACT_17015Metabolism of proteins
REACT_160078Peptide hormone metabolism
REACT_13698Regulation of beta-cell development
REACT_13819Regulation of gene expression in beta cells
REACT_18325Regulation of insulin secretion
REACT_1661SHC activation
REACT_999SHC-related events
REACT_508Signal attenuation
REACT_498Signaling by Insulin receptor
REACT_111102Signal Transduction
REACT_19189Synthesis, secretion, and deacylation of Ghrelin
SMP Pathway Links
SMP IDDescription
SMP00460Glibenclamide Action Pathway
SMP00461Gliclazide Action Pathway
SMP00391Insulin Signalling
SMP00682Leucine Stimulation on Insulin Signaling
SMP00453Nateglinide Action Pathway
SMP00643Pancreas Function
SMP00454Repaglinide Action Pathway
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