MGP Database

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MGP001636

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate-5-phosphatase, 40kDa
Protein EntryI5P1_HUMAN
UniProt IDQ14642
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
Catalytic ActivityD-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
FunctionMajor isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.
InteractionP08567:PLEK; NbExp=4; IntAct=EBI-8670520, EBI-2565501;
SimilarityBelongs to the inositol 1,4,5-trisphosphate 5- phosphatase type I family. {ECO:0000305}.
Subcellular LocationMembrane; Lipid-anchor.
Tissue SpecificityBrain; high level in Purkinje cells.
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