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MGP001640

Record overview

MGPD IDMGP001640
Gene ID3638
SpeciesHomo sapiens (Human)
Gene Nameinsulin induced gene 1
Gene Symbol INSIG1
SynonymsCL6; CL-6;
Alternate namesinsulin-induced gene 1 protein; INSIG-1 membrane protein;
Chromosome7
Map Location7q36
SummaryOxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009]
OrthologsView orthologs and multiple alignments for INSIG1

Proteins

insulin-induced gene 1 protein isoform 1
Refseq ID:NP_005533
Protein GI:28882053
UniProt ID:O15503
mRNA ID:NM_005542
Length:277
RefSeq Status:
MPRLHDHFWSCSCAHSARRRGPPRASAAGLAAKVGEMINVSVSGPSLLAAHGAPDADPAPRGRSAAMSGPEPGSPYPNTWHHRLLQRSLVLFSVGVVLAL
VLNLLQIQRNVTLFPEEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGL
WWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGVPEKPHSD
 
insulin-induced gene 1 protein isoform 2
Refseq ID:NP_938150
Protein GI:241982794
UniProt ID:O15503
mRNA ID:NM_198336
Length:178
RefSeq Status:
MPRLHDHFWSCSCAHSARRRGPPRASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIF
FSGGVTVGNIGRQLAMLIPFCEELNLKTTWLFHKTRSNYRVFLKSPIVIESSKPPILRARKILEENLTVDYDKDYLFS
 
insulin-induced gene 1 protein isoform 3
Refseq ID:NP_938151
Protein GI:38327531
UniProt ID:O15503
mRNA ID:NM_198337
Length:164
RefSeq Status:
MPRLHDHFWSCSCAHSARRRGPPRASAAGLAAKVGEMINVSVSGPSLLAAHGAPDADPAPRGRSAAMSGPEPGSPYPNTWHHRLLQRSLVLFSVGVVLAL
VLNLLQIQRNVTLFPEEVIATIFSSAWWVPPCCGTAAGIHPQISSIFVLGSLVYFSQEASRWGT
 
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