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MGP001662

UniProt Annotations

Entry Information

Gene Name	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Protein Entry	ITA3_HUMAN
UniProt ID	P26006
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha-3A; IsoId=P26006-2; Sequence=Displayed; Name=2; Synonyms=Alpha-3B; IsoId=P26006-1; Sequence=VSP_002721;
Disease	Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB) [MIM:614748]: A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease. {ECO:0000269\|PubMed:22512483}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function	Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269\|PubMed:10455171, ECO:0000269\|PubMed:15181153}.
Ptm	Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13- acetate stimulation. {ECO:0000269\|PubMed:9111516}.
Similarity	Belongs to the integrin alpha chain family. {ECO:0000305}.
Similarity	Contains 7 FG-GAP repeats. {ECO:0000305}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:15611341}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269\|PubMed:15611341}; Lipid-anchor {ECO:0000269\|PubMed:15611341}. Cell projection, invadopodium membrane {ECO:0000269\|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, filopodium membrane {ECO:0000269\|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. {ECO:0000269\|PubMed:10455171}.
Subunit	Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. {ECO:0000269\|PubMed:10455171, ECO:0000269\|PubMed:15181153}.
Tissue Specificity	Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. {ECO:0000269\|PubMed:9111516}.