MGP Database

MGP001663

Ontology/Pathway Information

Entrez Gene ID	3676
Gene Name	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Gene Symbol	ITGA4
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005911	IEA:Ensembl	C	cell-cell junction
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005925	IDA:UniProtKB	C	focal adhesion
GO:0034669	IDA:UniProtKB	C	integrin alpha4-beta7 complex
GO:0016020	IDA:UniProtKB	C	membrane
GO:0005886	IDA:UniProtKB	C	plasma membrane
GO:0050839	IMP:UniProtKB	F	cell adhesion molecule binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0030183	IC:BHF-UCL	P	B cell differentiation
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0001974	IEA:Ensembl	P	blood vessel remodeling
GO:0007160	IMP:UniProtKB	P	cell-matrix adhesion
GO:0003366	IMP:UniProtKB	P	cell-matrix adhesion involved in ameboidal cell migration
GO:0060710	IEA:Ensembl	P	chorio-allantoic fusion
GO:0035987	IEP:UniProtKB	P	endodermal cell differentiation
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0060324	IEA:Ensembl	P	face development
GO:0007507	IEA:Ensembl	P	heart development
GO:0007157	IEA:Ensembl	P	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0034113	IMP:UniProtKB	P	heterotypic cell-cell adhesion
GO:0007229	IEA:UniProtKB-KW	P	integrin-mediated signaling pathway
GO:0007159	IDA:BHF-UCL	P	leukocyte cell-cell adhesion
GO:0050900	TAS:Reactome	P	leukocyte migration
GO:0050901	IMP:UniProtKB	P	leukocyte tethering or rolling
GO:0090074	IDA:UniProtKB	P	negative regulation of protein homodimerization activity
GO:0043113	IMP:UniProtKB	P	receptor clustering
GO:0050776	TAS:Reactome	P	regulation of immune response
GO:0034446	IMP:UniProtKB	P	substrate adhesion-dependent cell spreading
GO:0072678	IEA:Ensembl	P	T cell migration

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_75774	Adaptive Immune System
REACT_12051	Cell surface interactions at the vascular wall
REACT_118779	Extracellular matrix organization
REACT_604	Hemostasis
REACT_6900	Immune System
REACT_11152	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_13552	Integrin cell surface interactions