MGP Database

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MGP001663

UniProt Annotations

Entry Information
Gene Nameintegrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Protein EntryITA4_HUMAN
UniProt IDP13612
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13612-1; Sequence=Displayed; Name=2; IsoId=P13612-2; Sequence=VSP_056612, VSP_056613; Note=No experimental confirmation available.;
DomainThe SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion. {ECO:0000269|PubMed:9488735}.
FunctionIntegrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. {ECO:0000269|PubMed:19064666}.
InteractionP05556:ITGB1; NbExp=3; IntAct=EBI-703044, EBI-703066; P49023:PXN; NbExp=3; IntAct=EBI-703044, EBI-702209; O43294:TGFB1I1; NbExp=2; IntAct=EBI-703044, EBI-1051449;
PtmPhosphorylation on Ser-1027 inhibits PXN binding. {ECO:0000269|PubMed:11533025, ECO:0000269|PubMed:19690332}.
Sequence CautionSequence=AAB59613.1; Type=Frameshift; Positions=13; Evidence={ECO:0000305}; Sequence=CAA34852.1; Type=Frameshift; Positions=13; Evidence={ECO:0000305};
SimilarityBelongs to the integrin alpha chain family. {ECO:0000305}.
SimilarityContains 7 FG-GAP repeats. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Interacts with AMICA1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1 homodimerization. {ECO:0000269|PubMed:10604475, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9488735}.
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