MGP Database

MGP001664

Ontology/Pathway Information

Entrez Gene ID	3678
Gene Name	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Gene Symbol	ITGA5
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0071062	TAS:BHF-UCL	C	alphav-beta3 integrin-vitronectin complex
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0005737	IEA:Ensembl	C	cytoplasm
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0005925	IDA:UniProtKB	C	focal adhesion
GO:0008305	TAS:ProtInc	C	integrin complex
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0001726	TAS:HGNC	C	ruffle
GO:0045202	IEA:Ensembl	C	synapse
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0005161	TAS:BHF-UCL	F	platelet-derived growth factor receptor binding
GO:0043184	TAS:BHF-UCL	F	vascular endothelial growth factor receptor 2 binding
GO:0001525	TAS:BHF-UCL	P	angiogenesis
GO:0007411	TAS:Reactome	P	axon guidance
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0007155	TAS:ProtInc	P	cell adhesion
GO:0033631	IEA:Ensembl	P	cell-cell adhesion mediated by integrin
GO:0031589	IMP:UniProtKB	P	cell-substrate adhesion
GO:0007044	IEA:Ensembl	P	cell-substrate junction assembly
GO:0035987	IMP:UniProtKB	P	endodermal cell differentiation
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0007157	IEA:Ensembl	P	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0034113	IMP:UniProtKB	P	heterotypic cell-cell adhesion
GO:0007229	IEA:UniProtKB-KW	P	integrin-mediated signaling pathway
GO:0007159	IEA:Ensembl	P	leukocyte cell-cell adhesion
GO:0050900	TAS:Reactome	P	leukocyte migration
GO:0007613	IEA:Ensembl	P	memory
GO:2000811	IMP:UniProtKB	P	negative regulation of anoikis
GO:0030335	IEA:Ensembl	P	positive regulation of cell migration
GO:0010811	IEA:Ensembl	P	positive regulation of cell-substrate adhesion
GO:0050731	IMP:BHF-UCL	P	positive regulation of peptidyl-tyrosine phosphorylation
GO:0030949	TAS:BHF-UCL	P	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0016032	IEA:UniProtKB-KW	P	viral process
GO:0035313	IEP:BHF-UCL	P	wound healing, spreading of epidermal cells

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_18266	Axon guidance
REACT_12051	Cell surface interactions at the vascular wall
REACT_111045	Developmental Biology
REACT_150366	Elastic fibre formation
REACT_118779	Extracellular matrix organization
REACT_160131	Fibronectin matrix formation
REACT_604	Hemostasis
REACT_13552	Integrin cell surface interactions
REACT_22205	L1CAM interactions
REACT_22272	Signal transduction by L1