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MGP001664

UniProt Annotations

Entry Information
Gene Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Protein EntryITA5_HUMAN
UniProt IDP08648
SpeciesHuman
Comments
Comment typeDescription
FunctionIntegrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
InteractionP17813:ENG; NbExp=4; IntAct=EBI-1382311, EBI-2834630; Q9H0F6:SHARPIN; NbExp=4; IntAct=EBI-1382311, EBI-3942966;
PtmProteolytic cleavage by PCSK5 mediates activation of the precursor. {ECO:0000269|PubMed:22740495}.
SimilarityBelongs to the integrin alpha chain family. {ECO:0000305}.
SimilarityContains 7 FG-GAP repeats. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV- 1 Tat. Interacts with CIB1. {ECO:0000269|PubMed:10397733, ECO:0000269|PubMed:11912194, ECO:0000269|PubMed:16051604, ECO:0000269|PubMed:16754960, ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:24011356}.
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