MGP Database

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MGP001669

Ontology/Pathway Information

Entrez Gene ID3683
Gene Nameintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Gene Symbol ITGAL
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0009986 IDA:UniProtKBCcell surface
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0001772 IEA:EnsemblCimmunological synapse
GO:0034687 IDA:UniProtKBCintegrin alphaL-beta2 complex
GO:0008305 NAS:UniProtKBCintegrin complex
GO:0016020 IDA:UniProtKBCmembrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0050839 IMP:UniProtKBFcell adhesion molecule binding
GO:0030369 IMP:UniProtKBFICAM-3 receptor activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0050798 IEA:EnsemblPactivated T cell proliferation
GO:0007596 TAS:ReactomePblood coagulation
GO:0007155 NAS:UniProtKBPcell adhesion
GO:0007160 IMP:UniProtKBPcell-matrix adhesion
GO:0006928 TAS:ProtIncPcellular component movement
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0007157 IMP:BHF-UCLPheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0006954 NAS:UniProtKBPinflammatory response
GO:0007229 IEA:UniProtKB-KWPintegrin-mediated signaling pathway
GO:0007159 IMP:BHF-UCLPleukocyte cell-cell adhesion
GO:0050900 TAS:ReactomePleukocyte migration
GO:0050850 IEA:EnsemblPpositive regulation of calcium-mediated signaling
GO:0022409 IEA:EnsemblPpositive regulation of cell-cell adhesion
GO:0042102 IEA:EnsemblPpositive regulation of T cell proliferation
GO:0043113 IMP:UniProtKBPreceptor clustering
GO:0050776 TAS:ReactomePregulation of immune response
GO:0007165 NAS:UniProtKBPsignal transduction
GO:0002291 IMP:BHF-UCLPT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_12051Cell surface interactions at the vascular wall
REACT_118779Extracellular matrix organization
REACT_604Hemostasis
REACT_6900Immune System
REACT_11152Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_13552Integrin cell surface interactions
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