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MGP001669

UniProt Annotations

Entry Information
Gene Nameintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Protein EntryITAL_HUMAN
UniProt IDP20701
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P20701-1; Sequence=Displayed; Name=2; IsoId=P20701-2; Sequence=VSP_002738; Note=No experimental confirmation available.; Name=3; IsoId=P20701-3; Sequence=VSP_042842, VSP_042843;
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
FunctionIntegrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
InteractionQ9WMX2:- (xeno); NbExp=2; IntAct=EBI-961214, EBI-6863748; P08575:PTPRC; NbExp=2; IntAct=EBI-961214, EBI-1341;
SimilarityBelongs to the integrin alpha chain family. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule:PRU00219}.
SimilarityContains 7 FG-GAP repeats. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2. {ECO:0000269|PubMed:12526797}.
Tissue SpecificityLeukocytes.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/itgal/";
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