MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001670

UniProt Annotations

Entry Information
Gene Nameintegrin, alpha M (complement component 3 receptor 3 subunit)
Protein EntryITAM_HUMAN
UniProt IDP11215
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11215-1; Sequence=Displayed; Name=2; IsoId=P11215-2; Sequence=VSP_047365;
DiseaseSystemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
FunctionIntegrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
SimilarityBelongs to the integrin alpha chain family. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule:PRU00219}.
SimilarityContains 7 FG-GAP repeats. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3. {ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813}.
Tissue SpecificityPredominantly expressed in monocytes and granulocytes.
  logo