MGP Database

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MGP001671

Ontology/Pathway Information

Entrez Gene ID3685
Gene Nameintegrin, alpha V
Gene Symbol ITGAV
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0035867 IDA:BHF-UCLCalphav-beta3 integrin-IGF-1-IGF1R complex
GO:0009986 IDA:UniProtKBCcell surface
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0031527 IDA:UniProtKBCfilopodium membrane
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0005887 NAS:UniProtKBCintegral component of plasma membrane
GO:0034683 IDA:UniProtKBCintegrin alphav-beta3 complex
GO:0034684 IDA:UniProtKBCintegrin alphav-beta5 complex
GO:0034686 IDA:UniProtKBCintegrin alphav-beta8 complex
GO:0008305 NAS:UniProtKBCintegrin complex
GO:0031258 IDA:UniProtKBClamellipodium membrane
GO:0016020 ISS:BHF-UCLCmembrane
GO:0031528 IDA:UniProtKBCmicrovillus membrane
GO:0045335 TAS:ReactomeCphagocytic vesicle
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0032587 IDA:UniProtKBCruffle membrane
GO:0050840 IDA:UniProtKBFextracellular matrix binding
GO:1990430 IDA:UniProtKBFextracellular matrix protein binding
GO:0001968 IDA:UniProtKBFfibronectin binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0002020 IDA:UniProtKBFprotease binding
GO:0050431 ISS:BHF-UCLFtransforming growth factor beta binding
GO:0001618 IEA:UniProtKB-KWFvirus receptor activity
GO:0005245 IDA:UniProtKBFvoltage-gated calcium channel activity
GO:0001525 IEP:UniProtKBPangiogenesis
GO:0042590 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474 TAS:ReactomePantigen processing and presentation of peptide antigen via MHC class I
GO:0038027 IMP:UniProtKBPapolipoprotein A-I-mediated signaling pathway
GO:0043277 IEA:EnsemblPapoptotic cell clearance
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0070588 IDA:UniProtKBPcalcium ion transmembrane transport
GO:0007155 IDA:BHF-UCLPcell adhesion
GO:0016049 IMP:UniProtKBPcell growth
GO:0007160 IDA:UniProtKBPcell-matrix adhesion
GO:0016477 IMP:UniProtKBPcell migration
GO:0031589 IMP:UniProtKBPcell-substrate adhesion
GO:0035987 IMP:UniProtKBPendodermal cell differentiation
GO:0052066 NAS:BHF-UCLPentry of symbiont into host cell by promotion of host phagocytosis
GO:0070371 ISS:BHF-UCLPERK1 and ERK2 cascade
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0097192 ISS:BHF-UCLPextrinsic apoptotic signaling pathway in absence of ligand
GO:0034113 IMP:UniProtKBPheterotypic cell-cell adhesion
GO:0007229 NAS:UniProtKBPintegrin-mediated signaling pathway
GO:0050900 TAS:ReactomePleukocyte migration
GO:0050919 IMP:UniProtKBPnegative chemotaxis
GO:2000536 IDA:BHF-UCLPnegative regulation of entry of bacterium into host cell
GO:2001237 IMP:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway
GO:0010888 IMP:BHF-UCLPnegative regulation of lipid storage
GO:0032369 IMP:BHF-UCLPnegative regulation of lipid transport
GO:0050748 IMP:BHF-UCLPnegative regulation of lipoprotein metabolic process
GO:0045715 IMP:BHF-UCLPnegative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0010745 IMP:BHF-UCLPnegative regulation of macrophage derived foam cell differentiation
GO:0045785 IDA:BHF-UCLPpositive regulation of cell adhesion
GO:0030335 IEA:EnsemblPpositive regulation of cell migration
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0033690 IEA:EnsemblPpositive regulation of osteoblast proliferation
GO:2000425 ISS:BHF-UCLPregulation of apoptotic cell clearance
GO:0050764 IDA:BHF-UCLPregulation of phagocytosis
GO:0034446 IDA:UniProtKBPsubstrate adhesion-dependent cell spreading
GO:0046718 IMP:UniProtKBPviral entry into host cell
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_111119Antigen processing-Cross presentation
REACT_18266Axon guidance
REACT_12051Cell surface interactions at the vascular wall
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_111174Cross-presentation of particulate exogenous antigens (phagosomes)
REACT_111045Developmental Biology
REACT_163906ECM proteoglycans
REACT_150366Elastic fibre formation
REACT_118779Extracellular matrix organization
REACT_604Hemostasis
REACT_6900Immune System
REACT_13552Integrin cell surface interactions
REACT_22205L1CAM interactions
REACT_169262Laminin interactions
REACT_150331Molecules associated with elastic fibres
REACT_163874Non-integrin membrane-ECM interactions
REACT_12519PECAM1 interactions
REACT_12529Signaling by VEGF
REACT_111102Signal Transduction
REACT_22272Signal transduction by L1
REACT_163942Syndecan interactions
REACT_264464VEGFA-VEGFR2 Pathway
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