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MGP001671

UniProt Annotations

Entry Information
Gene Nameintegrin, alpha V
Protein EntryITAV_HUMAN
UniProt IDP06756
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P06756-1; Sequence=Displayed; Name=2; IsoId=P06756-2; Sequence=VSP_024351; Note=No experimental confirmation available.; Name=3; IsoId=P06756-3; Sequence=VSP_044914; Note=No experimental confirmation available.;
FunctionThe alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
InteractionP05106:ITGB3; NbExp=11; IntAct=EBI-298282, EBI-702847; P18084:ITGB5; NbExp=2; IntAct=EBI-298282, EBI-1223434;
Sequence CautionSequence=BAD93131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the integrin alpha chain family. {ECO:0000305}.
SimilarityContains 7 FG-GAP repeats. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. lpha-V (ITGAV) associates with either beta-1 (ITGB1), beta-3 (ITGB3), beta-5 (ITGB5), beta-6 (ITGB6) or beta-8 (ITGB8). Interacts with CIB1 (PubMed:24011356). Interacts with RAB25 (PubMed:17925226). Integrins ITGAV:ITGB3 and ITGAV:ITGB5 interact with FBLN5 (via N-terminus) (By similarity). Interacts with HIV-1 Tat (PubMed:10397733). Alpha-V/beta-6 binds to foot- and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. Alpha-V/beta-3 interacts with herpes virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus. {ECO:0000250|UniProtKB:P43406, ECO:0000250|UniProtKB:P80746, ECO:0000269|PubMed:10397733, ECO:0000269|PubMed:10799568, ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:17925226, ECO:0000269|PubMed:18045938, ECO:0000269|PubMed:24011356, ECO:0000269|PubMed:9426447}.
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