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MGP001676

UniProt Annotations

Entry Information
Gene Nameintegrin, beta 5
Protein EntryITB5_HUMAN
UniProt IDP18084
SpeciesHuman
Comments
Comment typeDescription
FunctionIntegrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
InteractionQ9BY76:ANGPTL4; NbExp=3; IntAct=EBI-1223434, EBI-2968146; P06756:ITGAV; NbExp=2; IntAct=EBI-1223434, EBI-298282; Q9HD67:MYO10; NbExp=2; IntAct=EBI-1223434, EBI-307061; P97479:Myo7a (xeno); NbExp=8; IntAct=EBI-1223434, EBI-1149557;
SimilarityBelongs to the integrin beta chain family. {ECO:0000305}.
SimilarityContains 1 PSI domain. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10 (PubMed:15156152). Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus) (By similarity). {ECO:0000250|UniProtKB:O70309, ECO:0000269|PubMed:15156152}.
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