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MGP001680

Record overview

MGPD IDMGP001680
Gene ID3702
SpeciesHomo sapiens (Human)
Gene NameIL2-inducible T-cell kinase
Gene Symbol ITK
SynonymsEMT; LYK; LPFS1; PSCTK2;
Alternate namestyrosine-protein kinase ITK/TSK; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of mouse T-cell itk/tsk; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; kinase EMT; tyrosine-protein kinase LYK;
Chromosome5
Map Location5q31-q32
EC Number2.7.10.2
SummaryThis gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ITK

Proteins

tyrosine-protein kinase ITK/TSK
Refseq ID:NP_005537
Protein GI:15718680
UniProt ID:Q08881
mRNA ID:NM_005546
Length:620
RefSeq Status:
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQ
RWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCL
LDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSE
EDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSD
FGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
 
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