MGP Database

MGP001680

Ontology/Pathway Information

Entrez Gene ID3702
Gene NameIL2-inducible T-cell kinase
Gene Symbol ITK
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0005829 TAS:ReactomeCcytosol
GO:0031234 IBA:GO_CentralCextrinsic component of cytoplasmic side of plasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004715 IDA:UniProtKBFnon-membrane spanning protein tyrosine kinase activity
GO:0007202 ISS:UniProtKBPactivation of phospholipase C activity
GO:0002250 ISS:UniProtKBPadaptive immune response
GO:0006968 TAS:ProtIncPcellular defense response
GO:0001816 ISS:UniProtKBPcytokine production
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0045087 IBA:GO_CentralPinnate immune response
GO:0032609 IEA:EnsemblPinterferon-gamma production
GO:0032633 IEA:EnsemblPinterleukin-4 production
GO:0035556 IEA:InterProPintracellular signal transduction
GO:0001865 IBA:GO_CentralPNK T cell differentiation
GO:0038083 IBA:GO_CentralPpeptidyl-tyrosine autophosphorylation
GO:0042127 IBA:GO_CentralPregulation of cell proliferation
GO:0007165 TAS:ProtIncPsignal transduction
GO:0042110 TAS:UniProtKBPT cell activation
GO:0050852 ISS:UniProtKBPT cell receptor signaling pathway
GO:0007169 IBA:GO_CentralPtransmembrane receptor protein tyrosine kinase signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_12623Generation of second messenger molecules
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_12526TCR signaling
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