MGP Database

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MGP001688

Ontology/Pathway Information

Entrez Gene ID3710
Gene Nameinositol 1,4,5-trisphosphate receptor, type 3
Gene Symbol ITPR3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0045177 ISS:BHF-UCLCapical part of cell
GO:0005903 ISS:BHF-UCLCbrush border
GO:0005737 ISS:BHF-UCLCcytoplasm
GO:0005783 ISS:BHF-UCLCendoplasmic reticulum
GO:0005789 IDA:UniProtKBCendoplasmic reticulum membrane
GO:0005887 IDA:BHF-UCLCintegral component of plasma membrane
GO:0016020 IDA:UniProtKBCmembrane
GO:0043209 ISS:BHF-UCLCmyelin sheath
GO:0043025 ISS:BHF-UCLCneuronal cell body
GO:0005640 ISS:BHF-UCLCnuclear outer membrane
GO:0005730 IEA:EnsemblCnucleolus
GO:0005654 IEA:EnsemblCnucleoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0031095 TAS:ReactomeCplatelet dense tubular network membrane
GO:0043235 IDA:MGICreceptor complex
GO:0043533 ISS:BHF-UCLFinositol 1,3,4,5 tetrakisphosphate binding
GO:0070679 IDA:BHF-UCLFinositol 1,4,5 trisphosphate binding
GO:0005220 ISS:UniProtKBFinositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0000822 ISS:BHF-UCLFinositol hexakisphosphate binding
GO:0005218 ISS:UniProtKBFintracellular ligand-gated calcium channel activity
GO:0035091 IEA:EnsemblFphosphatidylinositol binding
GO:0007202 TAS:ReactomePactivation of phospholipase C activity
GO:0007596 TAS:ReactomePblood coagulation
GO:0060402 ISS:UniProtKBPcalcium ion transport into cytosol
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0007186 ISS:BHF-UCLPG-protein coupled receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0048016 IDA:GOCPinositol phosphate-mediated signaling
GO:0060291 IEA:EnsemblPlong-term synaptic potentiation
GO:0007613 IEA:EnsemblPmemory
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030168 TAS:ReactomePplatelet activation
GO:0007204 ISS:BHF-UCLPpositive regulation of cytosolic calcium ion concentration
GO:0051291 ISS:BHF-UCLPprotein heterooligomerization
GO:0051260 ISS:BHF-UCLPprotein homooligomerization
GO:0050796 TAS:ReactomePregulation of insulin secretion
GO:0051592 IDA:BHF-UCLPresponse to calcium ion
GO:0050913 IEA:EnsemblPsensory perception of bitter taste
GO:0050916 IEA:EnsemblPsensory perception of sweet taste
GO:0050917 IEA:EnsemblPsensory perception of umami taste
GO:0007165 TAS:ReactomePsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_264224beta-catenin independent WNT signaling
REACT_263982Ca2+ pathway
REACT_111064DAG and IP3 signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_2202Effects of PIP2 hydrolysis
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_162Elevation of cytosolic Ca2+ levels
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_19184GPCR downstream signaling
REACT_15526G-protein mediated events
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_15295Opioid Signalling
REACT_21310Phospholipase C-mediated cascade
REACT_798Platelet activation, signaling and aggregation
REACT_23905Platelet calcium homeostasis
REACT_23876Platelet homeostasis
REACT_15426PLC beta mediated events
REACT_115720PLCG1 events in ERBB2 signaling
REACT_12079PLC-gamma1 signalling
REACT_18325Regulation of insulin secretion
REACT_160158Role of phospholipids in phagocytosis
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_12529Signaling by VEGF
REACT_11045Signaling by Wnt
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
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