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MGP001688

UniProt Annotations

Entry Information
Gene Nameinositol 1,4,5-trisphosphate receptor, type 3
Protein EntryITPR3_HUMAN
UniProt IDQ14573
SpeciesHuman
Comments
Comment typeDescription
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
InteractionQ13507:TRPC3; NbExp=5; IntAct=EBI-351055, EBI-520807;
PtmPhosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity). {ECO:0000250}.
SimilarityBelongs to the InsP3 receptor family. {ECO:0000305}.
SimilarityContains 5 MIR domains. {ECO:0000255|PROSITE- ProRule:PRU00131}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitHomotetramer. Interacts with SIGMAR1, PML, AKT1, TRPC1, TRPC3 and TRPC4 (By similarity). Interacts with LRMP (via coiled- coil domain) (By similarity). Interacts with CABP1. Interacts with TMBIM4/LFG4. Interacts with CEMIP. Interacts with TESPA1 (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in intestinal crypt and villus epithelial cells.
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