MGP Database

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MGP001691

Ontology/Pathway Information

Entrez Gene ID3716
Gene NameJanus kinase 1
Gene Symbol JAK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005856 IEA:InterProCcytoskeleton
GO:0005829 TAS:ReactomeCcytosol
GO:0012505 IEA:UniProtKB-SubCellCendomembrane system
GO:0031234 IBA:GO_CentralCextrinsic component of cytoplasmic side of plasma membrane
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0005634 IDA:BHF-UCLCnucleus
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005131 ISS:BHF-UCLFgrowth hormone receptor binding
GO:0004715 IBA:GO_CentralFnon-membrane spanning protein tyrosine kinase activity
GO:0019903 IPI:UniProtKBFprotein phosphatase binding
GO:0004713 EXP:ReactomeFprotein tyrosine kinase activity
GO:0030154 IBA:GO_CentralPcell differentiation
GO:0016477 IBA:GO_CentralPcell migration
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0045087 IBA:GO_CentralPinnate immune response
GO:0060333 TAS:ReactomePinterferon-gamma-mediated signaling pathway
GO:0038110 IDA:UniProtKBPinterleukin-2-mediated signaling pathway
GO:0035556 TAS:ProtIncPintracellular signal transduction
GO:0038083 IBA:GO_CentralPpeptidyl-tyrosine autophosphorylation
GO:0006468 TAS:ProtIncPprotein phosphorylation
GO:0042127 IBA:GO_CentralPregulation of cell proliferation
GO:0060334 TAS:ReactomePregulation of interferon-gamma-mediated signaling pathway
GO:0060338 TAS:ReactomePregulation of type I interferon-mediated signaling pathway
GO:0046677 IDA:MGIPresponse to antibiotic
GO:0007169 IBA:GO_CentralPtransmembrane receptor protein tyrosine kinase signaling pathway
GO:0060337 TAS:ReactomePtype I interferon signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_115676Antiviral mechanism by IFN-stimulated genes
REACT_12002ARMS-mediated activation
REACT_18266Axon guidance
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_1391ERK1 activation
REACT_1183ERK2 activation
REACT_1482ERK activation
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_12076Frs2-mediated activation
REACT_21247FRS2-mediated cascade
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_25162Interferon alpha/beta signaling
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_27307Interleukin-6 signaling
REACT_115529Interleukin-7 signaling
REACT_23891Interleukin receptor SHC signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_115831ISG15 antiviral mechanism
REACT_21308MAP kinase activation in TLR cascade
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_18334NCAM signaling for neurite out-growth
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_798Platelet activation, signaling and aggregation
REACT_12005Prolonged ERK activation events
REACT_634RAF/MAP kinase cascade
REACT_25216Regulation of IFNA signaling
REACT_24980Regulation of IFNG signaling
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_524SOS-mediated signalling
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
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