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MGP001691

UniProt Annotations

Entry Information

Gene Name	Janus kinase 1
Protein Entry	JAK1_HUMAN
UniProt ID	P23458
Species	Human

Comments

Comment type	Description
Catalytic Activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255\|PROSITE- ProRule:PRU10028}.
Domain	Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1. {ECO:0000250}.
Domain	The FERM domain mediates interaction with JAKMIP1.
Function	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. {ECO:0000269\|PubMed:11909529}.
Interaction	P04626:ERBB2; NbExp=2; IntAct=EBI-1383438, EBI-641062; P48551:IFNAR2; NbExp=3; IntAct=EBI-1383438, EBI-958408;
Ptm	Phosphorylated. Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling. {ECO:0000269\|PubMed:11909529, ECO:0000269\|PubMed:19369195}.
Sequence Caution	Sequence=AAA36527.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA36527.1; Type=Frameshift; Positions=858, 862; Evidence={ECO:0000305};
Similarity	Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. {ECO:0000255\|PROSITE- ProRule:PRU00159}.
Similarity	Contains 1 FERM domain. {ECO:0000255\|PROSITE- ProRule:PRU00084}.
Similarity	Contains 1 SH2 domain. {ECO:0000255\|PROSITE- ProRule:PRU00191}.
Similarity	Contains 2 protein kinase domains. {ECO:0000255\|PROSITE-ProRule:PRU00159}.
Subcellular Location	Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
Subunit	Interacts with FER (By similarity). Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB. {ECO:0000250, ECO:0000269\|PubMed:12200137, ECO:0000269\|PubMed:15194700, ECO:0000269\|PubMed:15277531, ECO:0000269\|PubMed:7759950}.
Tissue Specificity	Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. {ECO:0000269\|PubMed:7896447}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/JAK1ID41031ch1p31.html";