MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001695

Ontology/Pathway Information

Entrez Gene ID3725
Gene Namejun proto-oncogene
Gene Symbol JUN
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IEA:EnsemblCcytosol
GO:0000228 TAS:ProtIncCnuclear chromosome
GO:0005719 IDA:BHF-UCLCnuclear euchromatin
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:ParkinsonsUK-UCLCnucleus
GO:0017053 IEA:EnsemblCtranscriptional repressor complex
GO:0005667 IEA:EnsemblCtranscription factor complex
GO:0035497 IDA:BHF-UCLFcAMP response element binding
GO:0003677 TAS:ProtIncFDNA binding
GO:0003690 IEA:EnsemblFdouble-stranded DNA binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0005100 IDA:UniProtKBFRho GTPase activator activity
GO:0001102 IPI:BHF-UCLFRNA polymerase II activating transcription factor binding
GO:0001077 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000980 IDA:BHF-UCLFRNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003705 IDA:UniProtKBFRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0001190 IC:BHF-UCLFRNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0070412 IPI:BHF-UCLFR-SMAD binding
GO:0000981 IC:ParkinsonsUK-UCLFsequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 IDA:BHF-UCLFsequence-specific DNA binding transcription factor activity
GO:0003713 IDA:UniProtKBFtranscription coactivator activity
GO:0008134 IPI:BHF-UCLFtranscription factor binding
GO:0044212 IDA:UniProtKBFtranscription regulatory region DNA binding
GO:0007568 IEA:EnsemblPaging
GO:0001525 IEA:EnsemblPangiogenesis
GO:0031103 IEA:EnsemblPaxon regeneration
GO:0071277 IEA:EnsemblPcellular response to calcium ion
GO:0051365 IEA:EnsemblPcellular response to potassium ion starvation
GO:0007623 IEA:EnsemblPcircadian rhythm
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0035026 IEA:EnsemblPleading edge cell differentiation
GO:0007612 IEA:EnsemblPlearning
GO:0001889 IEA:EnsemblPliver development
GO:0051899 IEA:EnsemblPmembrane depolarization
GO:0001774 IEA:EnsemblPmicroglial cell activation
GO:0030224 IEA:EnsemblPmonocyte differentiation
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0043922 IDA:UniProtKBPnegative regulation by host of viral transcription
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:0043392 IDA:UniProtKBPnegative regulation of DNA binding
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0031953 IEA:EnsemblPnegative regulation of protein autophosphorylation
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:1990441 IMP:ParkinsonsUK-UCLPnegative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0003151 IEA:EnsemblPoutflow tract morphogenesis
GO:0043923 IDA:UniProtKBPpositive regulation by host of viral transcription
GO:0045740 IEA:EnsemblPpositive regulation of DNA replication
GO:0001938 IEA:EnsemblPpositive regulation of endothelial cell proliferation
GO:0048146 IEA:EnsemblPpositive regulation of fibroblast proliferation
GO:0045657 IEA:EnsemblPpositive regulation of monocyte differentiation
GO:0043525 IEA:EnsemblPpositive regulation of neuron apoptotic process
GO:0032321 IDA:GOCPpositive regulation of Rho GTPase activity
GO:0048661 IEA:EnsemblPpositive regulation of smooth muscle cell proliferation
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0051726 IEA:EnsemblPregulation of cell cycle
GO:0051090 TAS:ReactomePregulation of sequence-specific DNA binding transcription factor activity
GO:0001836 IEA:EnsemblPrelease of cytochrome c from mitochondria
GO:0051591 IEA:EnsemblPresponse to cAMP
GO:0034097 IEA:EnsemblPresponse to cytokine
GO:0042493 IEA:EnsemblPresponse to drug
GO:0042542 IEA:EnsemblPresponse to hydrogen peroxide
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0009612 IEA:EnsemblPresponse to mechanical stimulus
GO:0009314 IEA:EnsemblPresponse to radiation
GO:0007184 IDA:BHF-UCLPSMAD protein import into nucleus
GO:0060395 IDA:BHF-UCLPSMAD protein signal transduction
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0007179 IDA:BHF-UCLPtransforming growth factor beta receptor signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_21326Activation of the AP-1 family of transcription factors
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_169436Oxidative Stress Induced Senescence
REACT_118744Pre-NOTCH Expression and Processing
REACT_118568Pre-NOTCH Transcription and Translation
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_299Signaling by NOTCH
REACT_111102Signal Transduction
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
  logo