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MGP001695

UniProt Annotations

Entry Information
Gene Namejun proto-oncogene
Protein EntryJUN_HUMAN
UniProt IDP05412
SpeciesHuman
Comments
Comment typeDescription
FunctionTranscription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:17210646}.
InteractionQ06481:APLP2; NbExp=3; IntAct=EBI-852823, EBI-79306; P05067:APP; NbExp=2; IntAct=EBI-852823, EBI-77613; P15336:ATF2; NbExp=5; IntAct=EBI-852823, EBI-1170906; P18848:ATF4; NbExp=2; IntAct=EBI-852823, EBI-492498; Q8IWZ6:BBS7; NbExp=3; IntAct=EBI-852823, EBI-1806001; Q99966:CITED1; NbExp=2; IntAct=EBI-852823, EBI-2624951; O43889:CREB3; NbExp=4; IntAct=EBI-852823, EBI-625002; P14921:ETS1; NbExp=3; IntAct=EBI-852823, EBI-913209; P01100:FOS; NbExp=21; IntAct=EBI-852823, EBI-852851; P07900:HSP90AA1; NbExp=2; IntAct=EBI-852823, EBI-296047; Q8WQG9:jnk-1 (xeno); NbExp=3; IntAct=EBI-852823, EBI-321822; P52292:KPNA2; NbExp=2; IntAct=EBI-852823, EBI-349938; P53779:MAPK10; NbExp=2; IntAct=EBI-852823, EBI-713543; P45983:MAPK8; NbExp=4; IntAct=EBI-852823, EBI-286483; P45983-1:MAPK8; NbExp=2; IntAct=EBI-852823, EBI-288687; Q9UPY8:MAPRE3; NbExp=3; IntAct=EBI-852823, EBI-726739; Q00987:MDM2; NbExp=3; IntAct=EBI-852823, EBI-389668; P48634:PRRC2A; NbExp=2; IntAct=EBI-852823, EBI-347545; Q9NRL3:STRN4; NbExp=3; IntAct=EBI-852823, EBI-717245; Q99986:VRK1; NbExp=4; IntAct=EBI-852823, EBI-1769146;
PtmAcetylated at Lys-271 by EP300. {ECO:0000269|PubMed:11689449}.
PtmPhosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr- 89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity. {ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18650425, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:8855261}.
SimilarityBelongs to the bZIP family. Jun subfamily. {ECO:0000305}.
SimilarityContains 1 bZIP (basic-leucine zipper) domain. {ECO:0000255|PROSITE-ProRule:PRU00978}.
Subcellular LocationNucleus.
SubunitHeterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with methylated RNF187. Binds to HIPK3. {ECO:0000250, ECO:0000269|PubMed:10196196, ECO:0000269|PubMed:10376527, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12087103, ECO:0000269|PubMed:15467742, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:20852630, ECO:0000269|PubMed:23624934, ECO:0000269|PubMed:8663478, ECO:0000269|PubMed:8837781, ECO:0000269|PubMed:9732876}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/JUNID151.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/jun/";
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