MGP Database

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MGP001697

Record overview

MGPD IDMGP001697
Gene ID3728
SpeciesHomo sapiens (Human)
Gene Namejunction plakoglobin
Gene Symbol JUP
SynonymsDP3; PDGB; PKGB; CTNNG; DPIII; ARVD12;
Alternate namesjunction plakoglobin; catenin (cadherin-associated protein), gamma 80kDa; desmoplakin III; desmoplakin-3;
Chromosome17
Map Location17q21
SummaryThis gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for JUP

Proteins

junction plakoglobin
Refseq ID:NP_068831
Protein GI:12056468
UniProt ID:P14923
mRNA ID:NM_021991
Length:745
RefSeq Status:
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSL
LLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLD
TARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ
ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQL
SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKA
TIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI
QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDAT
YRPMYSSDVPLDPLEMHMDMDGDYPIDTYSDGLRPPYPTADHMLA
 
junction plakoglobin
Refseq ID:NP_002221
Protein GI:4504811
UniProt ID:P14923
mRNA ID:NM_002230
Length:745
RefSeq Status:
Protein sequence is identical to GI:12056468 (mRNA isoform)
 
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