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MGP001720

Record overview

MGPD IDMGP001720
Gene ID3759
SpeciesHomo sapiens (Human)
Gene Namepotassium channel, inwardly rectifying subfamily J, member 2
Gene Symbol KCNJ2
SynonymsIRK1; LQT7; SQT3; ATFB9; HHIRK1; KIR2.1; HHBIRK1;
Alternate namesinward rectifier potassium channel 2; IRK-1; cardiac inward rectifier potassium channel; hIRK1; inward rectifier K+ channel KIR2.1; potassium inwardly-rectifying channel, subfamily J, member 2;
Chromosome17
Map Location17q24.3
SummaryPotassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for KCNJ2

Proteins

inward rectifier potassium channel 2
Refseq ID:NP_000882
Protein GI:4504835
UniProt ID:P63252
mRNA ID:NM_000891
Length:427
RefSeq Status:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFG
CVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAV
IAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEG
MVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTST
DTPPDIDLHNQASVPLEPRPLRRESEI
 
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