MGP Database

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MGP001720

Ontology/Pathway Information

Entrez Gene ID3759
Gene Namepotassium channel, inwardly rectifying subfamily J, member 2
Gene Symbol KCNJ2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0043197 IEA:EnsemblCdendritic spine
GO:0005794 IEA:EnsemblCGolgi apparatus
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0014704 IEA:EnsemblCintercalated disc
GO:0031224 IDA:UniProtKBCintrinsic component of membrane
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005791 IEA:EnsemblCrough endoplasmic reticulum
GO:0005790 IEA:EnsemblCsmooth endoplasmic reticulum
GO:0030315 IEA:EnsemblCT-tubule
GO:0008076 IDA:BHF-UCLCvoltage-gated potassium channel complex
GO:0005242 IDA:UniProtKBFinward rectifier potassium channel activity
GO:0005546 IDA:BHF-UCLFphosphatidylinositol-4,5-bisphosphate binding
GO:0086008 IMP:BHF-UCLFvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO:0086002 IMP:BHF-UCLPcardiac muscle cell action potential involved in contraction
GO:0030007 TAS:BHF-UCLPcellular potassium ion homeostasis
GO:0071260 IEA:EnsemblPcellular response to mechanical stimulus
GO:0015693 IEA:EnsemblPmagnesium ion transport
GO:0086012 TAS:BHF-UCLPmembrane depolarization during cardiac muscle cell action potential
GO:0086011 IMP:BHF-UCLPmembrane repolarization during action potential
GO:0086013 IMP:BHF-UCLPmembrane repolarization during cardiac muscle cell action potential
GO:1901381 IEA:EnsemblPpositive regulation of potassium ion transmembrane transport
GO:0010107 IDA:BHF-UCLPpotassium ion import
GO:0071805 IDA:BHF-UCLPpotassium ion transmembrane transport
GO:0006813 IDA:UniProtKBPpotassium ion transport
GO:0051289 IDA:UniProtKBPprotein homotetramerization
GO:0086091 IMP:BHF-UCLPregulation of heart rate by cardiac conduction
GO:0060306 IDA:BHF-UCLPregulation of membrane repolarization
GO:0060075 TAS:BHF-UCLPregulation of resting membrane potential
GO:0014861 IMP:BHF-UCLPregulation of skeletal muscle contraction via regulation of action potential
GO:0055119 IMP:BHF-UCLPrelaxation of cardiac muscle
GO:0090076 IMP:BHF-UCLPrelaxation of skeletal muscle
GO:0007268 TAS:ReactomePsynaptic transmission
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_25330Activation of GABAB receptors
REACT_75831Activation of G protein gated Potassium channels
REACT_75870Classical Kir channels
REACT_25031GABA B receptor activation
REACT_25199GABA receptor activation
REACT_75780G protein gated Potassium channels
REACT_25004Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REACT_75918Inwardly rectifying K+ channels
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_75908Potassium Channels
REACT_13477Transmission across Chemical Synapses
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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