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MGP001721

Record overview

MGPD IDMGP001721
Gene ID3760
SpeciesHomo sapiens (Human)
Gene Namepotassium channel, inwardly rectifying subfamily J, member 3
Gene Symbol KCNJ3
SynonymsKGA; GIRK1; KIR3.1;
Alternate namesG protein-activated inward rectifier potassium channel 1; GIRK-1; inward rectifier K(+) channel Kir3.1; inward rectifier K+ channel KIR3.1; potassium channel, inwardly rectifying subfamily J member 3; potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e; potassium inwardly-rectifying channel, subfamily J, member 3;
Chromosome2
Map Location2q24.1
SummaryPotassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]
OrthologsView orthologs and multiple alignments for KCNJ3

Proteins

G protein-activated inward rectifier potassium channel 1 isoform 1
Refseq ID:NP_002230
Protein GI:4504839
UniProt ID:P48549
mRNA ID:NM_002239
Length:501
RefSeq Status:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMAS
MWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHA
VISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE
GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLP
SKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPAKLRKMNSDRF
T
 
G protein-activated inward rectifier potassium channel 1 isoform 2
Refseq ID:NP_001247437
Protein GI:386781846
UniProt ID:P48549
mRNA ID:NM_001260508
Length:235
RefSeq Status:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMAS
MWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHA
VISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKG
 
G protein-activated inward rectifier potassium channel 1 isoform 3
Refseq ID:NP_001247438
Protein GI:386781850
UniProt ID:P48549
mRNA ID:NM_001260509
Length:308
RefSeq Status:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMAS
MWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHA
VISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE
GIVETTGE
 
G protein-activated inward rectifier potassium channel 1 isoform 4
Refseq ID:NP_001247439
Protein GI:386781858
UniProt ID:P48549
mRNA ID:NM_001260510
Length:253
RefSeq Status:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMAS
MWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHA
VISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKVSAPRPFPTGRPASPKPAE
 
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