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MGP001721

UniProt Annotations

Entry Information
Gene Namepotassium channel, inwardly rectifying subfamily J, member 3
Protein EntryKCNJ3_HUMAN
UniProt IDP48549
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48549-1; Sequence=Displayed; Name=2; IsoId=P48549-2; Sequence=VSP_045432, VSP_045433;
FunctionThis potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
SimilarityBelongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitAssociates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger (By similarity). {ECO:0000250}.
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