MGP Database

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MGP001722

UniProt Annotations

Entry Information
Gene Namepotassium channel, inwardly rectifying subfamily J, member 4
Protein EntryKCNJ4_HUMAN
UniProt IDP48050
SpeciesHuman
Comments
Comment typeDescription
DomainThe Val/Gly/Ala/Pro stretch may have a functional role in the conductance or permeation properties.
FunctionInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). {ECO:0000250}.
SimilarityBelongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization. {ECO:0000250}.
SubunitHomomultimeric and heteromultimeric association with KCNJ2 and KCNJ12. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity). Interacts with TAX1BP3. TAX1BP3 competes with LIN7 family members for KCNJ4 binding. {ECO:0000250, ECO:0000269|PubMed:12032359, ECO:0000269|PubMed:19635485}.
Tissue SpecificityHeart, skeletal muscle, and several different brain regions including the hippocampus.
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