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MGP001739

Record overview

MGPD IDMGP001739
Gene ID3781
SpeciesHomo sapiens (Human)
Gene Namepotassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
Gene Symbol KCNN2
SynonymsSK2; hSK2; SKCA2; KCa2.2; SKCa 2;
Alternate namessmall conductance calcium-activated potassium channel protein 2; apamin-sensitive small-conductance Ca2+-activated potassium channel; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel 2;
Chromosome5
Map Location5q22.3
SummaryAction potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
OrthologsView orthologs and multiple alignments for KCNN2

Proteins

small conductance calcium-activated potassium channel protein 2 isoform a
Refseq ID:NP_067627
Protein GI:25777645
UniProt ID:Q9H2S1
mRNA ID:NM_021614
Length:579
RefSeq Status:
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSG
HGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDN
GADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRF
VMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELT
KAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERS
EDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
 
small conductance calcium-activated potassium channel protein 2 isoform b
Refseq ID:NP_740721
Protein GI:25777647
UniProt ID:Q9H2S1
mRNA ID:NM_170775
Length:231
RefSeq Status:
MWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKV
RKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYD
KHVTYNAERSRSSSRRRRSSSTAPPTSSESS
 
small conductance calcium-activated potassium channel protein 2 isoform b
Refseq ID:NP_001265133
Protein GI:501353609
UniProt ID:Q9H2S1
mRNA ID:NM_001278204
Length:231
RefSeq Status:
Protein sequence is identical to GI:25777647 (mRNA isoform)
 
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