MGP Database

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MGP001739

UniProt Annotations

Entry Information
Gene Namepotassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
Protein EntryKCNN2_HUMAN
UniProt IDQ9H2S1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H2S1-1; Sequence=Displayed; Name=2; IsoId=Q9H2S1-2; Sequence=VSP_044584;
FunctionForms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
SimilarityBelongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitHeterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in atrial myocytes (at protein level). Widely expressed. {ECO:0000269|PubMed:13679367}.
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